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GWAS Study

Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.

Jin Y, Birlea SA, Fain PR et al.

20410501 PubMed ID
GWAS Study Type
7656 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

JY
Jin Y
BS
Birlea SA
FP
Fain PR
GK
Gowan K
RS
Riccardi SL
HP
Holland PJ
MC
Mailloux CM
SA
Sufit AJ
HS
Hutton SM
AA
Amadi-Myers A
BD
Bennett DC
WM
Wallace MR
MW
McCormack WT
KE
Kemp EH
GD
Gawkrodger DJ
WA
Weetman AP
PM
Picardo M
LG
Leone G
TA
Taïeb A
JT
Jouary T
EK
Ezzedine K
VG
van Geel N
LJ
Lambert J
OA
Overbeck A
SR
Spritz RA
Chapter II

Abstract

Summary of the research findings

Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair, and is associated with an elevated risk of other autoimmune diseases.

1,392 European ancestry cases, 2,629 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

7656
Total Participants
GWAS
Study Type
Yes
Replicated
647 European ancestry cases, 1,056 European ancestry controls, 183 European ancestry trios, 1,383 European ancestry individuals from 332 families
Replication Participants
European
Ancestry
U.K.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.