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GWAS Study

Variant of TREM2 associated with the risk of Alzheimer's disease.

Jonsson T, Stefansson H, Steinberg S et al.

23150908 PubMed ID
GWAS Study Type
24202 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

JT
Jonsson T
SH
Stefansson H
SS
Steinberg S
JI
Jonsdottir I
JP
Jonsson PV
SJ
Snaedal J
BS
Bjornsson S
HJ
Huttenlocher J
LA
Levey AI
LJ
Lah JJ
RD
Rujescu D
HH
Hampel H
GI
Giegling I
AO
Andreassen OA
EK
Engedal K
UI
Ulstein I
DS
Djurovic S
IC
Ibrahim-Verbaas C
HA
Hofman A
IM
Ikram MA
VD
van Duijn CM
TU
Thorsteinsdottir U
KA
Kong A
SK
Stefansson K
Chapter II

Abstract

Summary of the research findings

Sequence variants, including the ε4 allele of apolipoprotein E, have been associated with the risk of the common late-onset form of Alzheimer's disease. Few rare variants affecting the risk of late-onset Alzheimer's disease have been found.

3,550 European ancestry cases, 8,888 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

24202
Total Participants
GWAS
Study Type
Yes
Replicated
694 European ancestry cases, 4,375 European ancestry controls, 1,343 cases, 5,352 controls
Replication Participants
European
Ancestry
U.S., Netherlands, Iceland, Germany, Norway
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.