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GWAS Study

A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.

Levin AM, Mathias RA, Huang L et al.

23146381 PubMed ID
GWAS Study Type
10059 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

LA
Levin AM
MR
Mathias RA
HL
Huang L
RL
Roth LA
DD
Daley D
MR
Myers RA
HB
Himes BE
RI
Romieu I
YM
Yang M
EC
Eng C
PJ
Park JE
ZK
Zoratti K
GC
Gignoux CR
TD
Torgerson DG
GJ
Galanter JM
HS
Huntsman S
NE
Nguyen EA
BA
Becker AB
CM
Chan-Yeung M
KA
Kozyrskyj AL
KP
Kwok PY
GF
Gilliland FD
GW
Gauderman WJ
BE
Bleecker ER
RB
Raby BA
MD
Meyers DA
LS
London SJ
MF
Martinez FD
WS
Weiss ST
BE
Burchard EG
ND
Nicolae DL
OC
Ober C
BK
Barnes KC
WL
Williams LK
Chapter II

Abstract

Summary of the research findings

IgE is both a marker and mediator of allergic inflammation. Despite reported differences in serum total IgE levels by race-ethnicity, African American and Latino subjects have not been well represented in genetic studies of total IgE.

2,469 African American individuals, 259 Latino individuals, 1,564 European ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

10059
Total Participants
GWAS
Study Type
Yes
Replicated
2,961 African American individuals, 1,477 Latino individuals, 649 European ancestry individuals, 680 Hutterite individuals
Replication Participants
European, African American or Afro-Caribbean, Hispanic or Latin American
Ancestry
U.S., Canada, Barbados, Puerto Rico, Mexico
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.