Estimating the heritability of reporting stressful life events captured by common genetic variants.
Power RA, Wingenbach T, Cohen-Woods S et al.
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Abstract
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Although usually thought of as external environmental stressors, a significant heritable component has been reported for measures of stressful life events (SLEs) in twin studies. Method We examined the variance in SLEs captured by common genetic variants from a genome-wide association study (GWAS) of 2578 individuals. Genome-wide complex trait analysis (GCTA) was used to estimate the phenotypic variance tagged by single nucleotide polymorphisms (SNPs). We also performed a GWAS on the number of SLEs, and looked at correlations between siblings.
2,578 European ancestry depression cases and controls
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