Family-based association analysis of alcohol dependence criteria and severity.
Wetherill L, Kapoor M, Agrawal A et al.
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Abstract
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Despite the high heritability of alcohol dependence (AD), the genes found to be associated with it account for only a small proportion of its total variability. The goal of this study was to identify and analyze phenotypes based on homogeneous classes of individuals to increase the power to detect genetic risk factors contributing to the risk of AD.
up to 2,322 European ancestry individuals from 118 families
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