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GWAS Study

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank.

Wain LV, Shrine N, Miller S et al.

26423011 PubMed ID
GWAS Study Type
14654 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

WL
Wain LV
SN
Shrine N
MS
Miller S
JV
Jackson VE
NI
Ntalla I
SA
Soler Artigas M
BC
Billington CK
KA
Kheirallah AK
AR
Allen R
CJ
Cook JP
PK
Probert K
OM
Obeidat M
BY
Bossé Y
HK
Hao K
PD
Postma DS
PP
Paré PD
RA
Ramasamy A
MR
Mägi R
ME
Mihailov E
RE
Reinmaa E
ME
Melén E
OJ
O'Connell J
FE
Frangou E
DO
Delaneau O
FC
Freeman C
PD
Petkova D
MM
McCarthy M
SI
Sayers I
DP
Deloukas P
HR
Hubbard R
PI
Pavord I
HA
Hansell AL
TN
Thomson NC
ZE
Zeggini E
MA
Morris AP
MJ
Marchini J
SD
Strachan DP
TM
Tobin MD
HI
Hall IP
Chapter II

Abstract

Summary of the research findings

Understanding the genetic basis of airflow obstruction and smoking behaviour is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD). We used UK Biobank data to study the genetic causes of smoking behaviour and lung health.

9,748 European ancestry individuals with low FEV1 measurements, 4,906 European ancestry individuals with high FEV1 measurements

Chapter III

Study Statistics

Key metrics and study information

14654
Total Participants
GWAS
Study Type
No
Replicated
European
Ancestry
U.K.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.