Shared genetic architecture between COVID-19 and irritable bowel syndrome: a large-scale genome-wide cross-trait analysis.
Liu X, Li D, Gao W et al.
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Abstract
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It has been reported that COVID-19 patients have an increased risk of developing IBS; however, the underlying genetic mechanisms of these associations remain largely unknown. The aim of this study was to investigate potential shared SNPs, genes, proteins, and biological pathways between COVID-19 and IBS by assessing pairwise genetic correlations and cross-trait genetic analysis.
63,729 European ancestry IBS cases, 122,616 European ancestry COVID-19 cases, 32,519 European ancestry hospitalized COVID-19 cases, 5,300,627 European ancestry controls
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