Genome-wide association and replication study of anti-tuberculosis drugs-induced liver toxicity.
Petros Z, Lee MM, Takahashi A et al.
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Abstract
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Drug-induced liver injury (DILI) is a well-recognized adverse event of anti tuberculosis drugs (ATD) possibly associated with genetic variations. The objective of this study was to perform genome-wide association study (GWAS) to identify genetic variants associated with the risk for ATD induced liver toxicity in Ethiopian patients.
48 Ethiopian cases with liver injury, 354 Ethiopian cases without liver injury
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