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GWAS Study

Genomewide association study of peanut allergy reproduces association with amino acid polymorphisms in HLA-DRB1.

Martino DJ, Ashley S, Koplin J et al.

27883235 PubMed ID
GWAS Study Type
5507 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

MD
Martino DJ
AS
Ashley S
KJ
Koplin J
EJ
Ellis J
SR
Saffery R
DS
Dharmage SC
GL
Gurrin L
MM
Matheson MC
KB
Kalb B
MI
Marenholz I
BK
Beyer K
LY
Lee YA
HX
Hong X
WX
Wang X
VD
Vukcevic D
MA
Motyer A
LS
Leslie S
AK
Allen KJ
FM
Ferreira MA
Chapter II

Abstract

Summary of the research findings

Genetic variants for IgE-mediated peanut allergy are yet to be fully characterized and to date only one genomewide association study (GWAS) has been published.

51 European ancestry infant cases, 14 Asian ancestry infant cases, 8 mixed European/Asian infant cases, 119 European ancestry non-allergic infant controls, 10 Asian ancestry non-allergic infant controls, 19 mixed European/Asian non-allergic infant controls

Chapter III

Study Statistics

Key metrics and study information

5507
Total Participants
GWAS
Study Type
Yes
Replicated
604 European ancestry infant cases, 34 mixed European/Asian infant cases, 2,871 European ancestry non-allergic infant controls, 40 mixed European/Asian non-allergic infant controls, 589 European ancestry infant controls, 1,148 European ancestry parent controls
Replication Participants
Asian unspecified, European, Other
Ancestry
Australia, U.S., Germany
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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Analysis In Progress

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