A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
Noordam R, Sitlani CM, Avery CL et al.
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Abstract
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Increased heart rate and a prolonged QT interval are important risk factors for cardiovascular morbidity and mortality, and can be influenced by the use of various medications, including tricyclic/tetracyclic antidepressants (TCAs). We aim to identify genetic loci that modify the association between TCA use and RR and QT intervals.
1,250 European ancestry users, 295 African American users, 1,886 Hispanic or Latino ancestry users, 40,701 European ancestry non-users, 9,940 African American non-users, 67,863 Hispanic or Latino ancestry non-users
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