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GWAS Study

Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.

Nicoletti P, Aithal GP, Bjornsson ES et al.

28043905 PubMed ID
GWAS Study Type
10602 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

NP
Nicoletti P
AG
Aithal GP
BE
Bjornsson ES
AR
Andrade RJ
SA
Sawle A
AM
Arrese M
BH
Barnhart HX
BE
Bondon-Guitton E
HP
Hayashi PH
BF
Bessone F
CA
Carvajal A
CI
Cascorbi I
CE
Cirulli ET
CN
Chalasani N
CA
Conforti A
CS
Coulthard SA
DM
Daly MJ
DC
Day CP
DJ
Dillon JF
FR
Fontana RJ
GJ
Grove JI
HP
Hallberg P
HN
Hernández N
IL
Ibáñez L
KG
Kullak-Ublick GA
LT
Laitinen T
LD
Larrey D
LM
Lucena MI
MD
Maitland-van der Zee AH
MJ
Martin JH
MM
Molokhia M
PM
Pirmohamed M
PE
Powell EE
QS
Qin S
SJ
Serrano J
SC
Stephens C
SA
Stolz A
WM
Wadelius M
WP
Watkins PB
FA
Floratos A
SY
Shen Y
NM
Nelson MR
UT
Urban TJ
DA
Daly AK
Chapter II

Abstract

Summary of the research findings

Background & aims: We performed a genome-wide association study (GWAS) to identify genetic risk factors for drug-induced liver injury (DILI) from licensed drugs without previously reported genetic risk factors.

14 European ancestry cases, 10,588 European ancestry controls.

Chapter III

Study Statistics

Key metrics and study information

10602
Total Participants
GWAS
Study Type
No
Replicated
European
Ancestry
Argentina, Finland, Sweden, U.S., Australia, Italy, Netherlands, Chile, Germany, U.K., Uruguay, Switzerland, Spain, France
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.