Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
Graff M, Scott RA, Justice AE et al.
Publication Details
Comprehensive information about this research publication
Authors
Abstract
Summary of the research findings
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
2,518 African American women, 83,707 European ancestry women, 1,773 Filipino ancestry women, 1,030 Indian ancestry women, 1,457 African American men, 52,993 European ancestry men, 7,648 Indian ancestry men, 5,527 European ancestry individuals
Study Statistics
Key metrics and study information
Analysis
Comprehensive review of health and genetic findings
Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.
Analysis In Progress
Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.
Summary
Key Findings
Health Insights
Disease Analysis
Genetic Trait Analysis
Clinical Relevance
Scientific Assessment
Related Publications
Other publications that may be of interest
Genetic determinants of zinc homeostasis and its role in cardiometabolic diseases.
Sadler MC
PLoS Genet
Urinary zinc levels
Gene burden analysis identifies genes associated with increased risk and severity of adult-onset hearing loss in a diverse hospital-based cohort.
Hui D
PLoS Genet
Hearing loss
Sub-cellular level resolution of common genetic variation in the photoreceptor layer identifies continuum between rare disease and common variation.
Currant H
PLoS Genet
Outer nuclear layer (ONL) thickness
A comprehensive genome-wide cross-trait analysis of sexual factors and uterine leiomyoma.
Wu X
PLoS Genet
Age at first sexual intercourse or uterine leiomyoma (pleiotropy)
Genetic regulators of sputum mucin concentration and their associations with COPD phenotypes.
Buren EV
PLoS Genet
MUC5B concentration x pack-years of smoking interaction (2df)
Explore More Research
Discover the latest findings in health and genetic research