Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study.
Hayden LP, Cho MH, Raby BA et al.
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Abstract
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Childhood asthma is strongly influenced by genetics and is a risk factor for reduced lung function and chronic obstructive pulmonary disease (COPD) in adults. This study investigates self-reported childhood asthma in adult smokers from the COPDGene Study. We hypothesize that childhood asthma is associated with decreased lung function, increased risk for COPD, and that a genome-wide association study (GWAS) will show association with established asthma variants.
385 European ancestry cases, 4979 European ancestry controls, 325 African American cases, 2342 African American controls
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