DSP variants may be associated with longitudinal change in quantitative emphysema.
Kim W, Cho MH, Sakornsakolpat P et al.
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Abstract
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Emphysema, characterized by lung destruction, is a key component of Chronic Obstructive Pulmonary Disease (COPD) and is associated with increased morbidity and mortality. Genome-wide association studies (GWAS) have identified multiple genetic factors associated with cross-sectional measures of quantitative emphysema, but the genetic determinants of longitudinal change in quantitative measures of emphysema remain largely unknown. Our study aims to identify genetic variants associated with longitudinal change in quantitative emphysema measured by computed tomography (CT) imaging.
4,427 European ancestry individuals, 1,158 African American individuals
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