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GWAS Study

Radiogenomics Consortium Genome-Wide Association Study Meta-analysis of Late Toxicity after Prostate Cancer Radiotherapy.

Kerns SL, Fachal L, Dorling L et al.

31095341 PubMed ID
GWAS Study Type
3379 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

KS
Kerns SL
FL
Fachal L
DL
Dorling L
BG
Barnett GC
BA
Baran A
PD
Peterson DR
HM
Hollenberg M
HK
Hao K
NA
Narzo AD
AM
Ahsen ME
PG
Pandey G
BS
Bentzen SM
JM
Janelsins M
ER
Elliott RM
PP
Pharoah PDP
BN
Burnet NG
DD
Dearnaley DP
GS
Gulliford SL
HE
Hall E
SM
Sydes MR
AM
Aguado-Barrera ME
GA
Gómez-Caamaño A
CA
Carballo AM
PP
Peleteiro P
LR
Lobato-Busto R
SR
Stock R
SN
Stone NN
OH
Ostrer H
UN
Usmani N
SS
Singhal S
TH
Tsuji H
IT
Imai T
SS
Saito S
ER
Eeles R
DK
DeRuyck K
PM
Parliament M
DA
Dunning AM
VA
Vega A
RB
Rosenstein BS
WC
West CML
Chapter II

Abstract

Summary of the research findings

A total of 10%-20% of patients develop long-term toxicity following radiotherapy for prostate cancer. Identification of common genetic variants associated with susceptibility to radiotoxicity might improve risk prediction and inform functional mechanistic studies.

3,379 European ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

3379
Total Participants
GWAS
Study Type
Yes
Replicated
538 Japanese ancestry individuals
Replication Participants
European, East Asian
Ancestry
Canada, U.S., Belgium, Spain, Japan
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.