Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy.
Trendowski MR, El-Charif O, Ratain MJ et al.
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Abstract
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Purpose: Serum platinum is measurable for years after completion of cisplatin-based chemotherapy (CBC). We report the largest investigation of serum platinum levels to date of 1,010 testicular cancer survivors (TCS) assessed 1-35 years after CBC and evaluate genetic contributions to these levels.
866 European ancestry individuals, 17 non-European ancestry individuals, 127 individuals
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