Genome-wide association study reveals two novel risk alleles for incident obstructive sleep apnea in the EPISONO cohort.
Farias Tempaku P, Leite Santoro M, Bittencourt L et al.
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Abstract
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Objective/background: Obstructive sleep apnea (OSA) is a sleep-related breathing disorder that has a complex phenotype. Currently, few genes have been linked with OSA. Thus, the aim of this study was to conduct a genome-wide association study (GWAS) of the apnea-hypopnea index (AHI) variation along time (delta-AHI) in a prospective cohort.
404 European ancestry individuals, 97 Black individuals, 20 Asian ancestry individuals, 20 Indigenous individuals, 138 mixed race individuals, 27 individuals
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