Integrative omics provide biological and clinical insights into acute respiratory distress syndrome.
Du M, Garcia JGN, Christie JD et al.
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Abstract
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Purpose: Acute respiratory distress syndrome (ARDS) is accompanied by a dysfunctional immune-inflammatory response following lung injury, including during coronavirus disease 2019 (COVID-19). Limited causal biomarkers exist for ARDS development. We sought to identify novel genetic susceptibility targets for ARDS to focus further investigation on their biological mechanism and therapeutic potential.
1,250 European ancestry cases, 1,583 European ancestry controls, 387 African American cases, 387 African American controls
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