Novel Role for Caspase Recruitment Domain Family Member 14 and its Genetic Variant rs11652075 in Skin Filaggrin Homeostasis.
DeVore SB, Stevens ML, He H et al.
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Abstract
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Low epidermal filaggrin (FLG) is a risk factor for atopic dermatitis (AD) and allergic comorbidity. FLG mutations do not fully explain the variation in epidermal FLG levels, highlighting that other genetic loci may also regulate FLG expression.
235 Black or unknown ancestry individuals
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