Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology.
van der Meer D, Shadrin AA, O'Connell K et al.
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Abstract
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Schizophrenia is a complex polygenic disorder with subtle, distributed abnormalities in brain morphology. There are indications of shared genetic architecture between schizophrenia and brain measures despite low genetic correlations. Through the use of analytical methods that allow for mixed directions of effects, this overlap may be leveraged to improve our understanding of underlying mechanisms of schizophrenia and enrich polygenic risk prediction outcome.
33,735 white British ancestry individuals
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