Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations.
Temprano-Sagrera G, Sitlani CM, Bone WP et al.
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Abstract
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Multi-phenotype analysis of genetically correlated phenotypes can increase the statistical power to detect loci associated with multiple traits, leading to the discovery of novel loci. This is the first study to date to comprehensively analyze the shared genetic effects within different hemostatic traits, and between these and their associated disease outcomes.
32,610 European, African American, East Asian, South Asian or Hispanic individuals with factor VIII measurements, 26,929 European ancestry individuals with tPA measurements, 46,354 European, African American or Hispanic individuals with vWF measurements
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