Sex-specific genetic modifiers identified susceptibility of cold stored red blood cells to osmotic hemolysis.
Fang F, Hazegh K, Mast AE et al.
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Abstract
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Genetic variants have been found to influence red blood cell (RBC) susceptibility to hemolytic stress and affect transfusion outcomes and the severity of blood diseases. Males have a higher susceptibility to hemolysis than females, but little is known about the genetic mechanism contributing to the difference.
3,975 European ancestry men, 694 African American men, 807 Asian ancestry men, 378 Hispanic men, 274 men
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