Causality of abdominal obesity on cognition: a trans-ethnic Mendelian randomization study.
Wang SH, Su MH, Chen CY et al.
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Abstract
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Obesity has been associated with cognition in observational studies; however, whether its effect is confounding or a reverse causality remains inconclusive. This study aimed to investigate the causal relationships of overall obesity, measured by body mass index (BMI), and abdominal adiposity, measured by waist-hip ratio adjusted for BMI (WHRadjBMI), and cognition across European and Asian populations using Mendelian randomization (MR) analysis.
65,683 Asian ancestry individuals
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