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GWAS Study

Genome-wide Association Study Shows That Executive Functioning Is Influenced by GABAergic Processes and Is a Neurocognitive Genetic Correlate of Psychiatric Disorders.

Hatoum AS, Morrison CL, Mitchell EC et al.

36150907 PubMed ID
GWAS Study Type
427037 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

HA
Hatoum AS
MC
Morrison CL
ME
Mitchell EC
LM
Lam M
BC
Benca-Bachman CE
RA
Reineberg AE
PR
Palmer RHC
EL
Evans LM
KM
Keller MC
FN
Friedman NP
Chapter II

Abstract

Summary of the research findings

Deficits in executive functions (EFs), cognitive processes that control goal-directed behaviors, are associated with psychopathology and neurologic disorders. Little is known about the molecular bases of individual differences in EFs. Prior candidate gene studies have been underpowered in their search for dopaminergic processes involved in cognitive functioning, and existing genome-wide association studies of EFs used small sample sizes and/or focused on individual tasks that are imprecise measures of EFs.

427,037 European ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

427037
Total Participants
GWAS
Study Type
No
Replicated
European
Ancestry
U.K.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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Analysis In Progress

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