Impact of Genetic Variations on Thromboembolic Risk in Saudis with Sickle Cell Disease.
Alshabeeb MA, Alwadaani D, Al Qahtani FH et al.
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Abstract
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Sickle cell disease (SCD) is a Mendelian disease characterized by multigenic phenotypes. Previous reports indicated a higher rate of thromboembolic events (TEEs) in SCD patients. A number of candidate polymorphisms in certain genes (e.g., FVL, PRT, and MTHFR) were previously reported as risk factors for TEEs in different clinical conditions. This study aimed to genotype these genes and other loci predicted to underlie TEEs in SCD patients.
65 Saudis ancestry cases, 285 Saudis ancestry controls
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