Uncommon protein-coding variants associated with suicide attempt in a diverse sample of US Army soldiers.
Wilkerson MD, Hupalo D, Gray JC et al.
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Abstract
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Suicide is a societal and public health concern of global scale. Identifying genetic risk factors for suicide attempt can characterize underlying biology and enable early interventions to prevent deaths. Recent studies have described common genetic variants for suicide-related behaviors. Here, we advance this search for genetic risk by analyzing the association between suicide attempt and uncommon variation exome-wide in a large, ancestrally diverse sample.
2,151 Admixed American ancestry individuals, 1,800 African ancestry individuals, 362 East Asian ancestry individuals, 8,811 European ancestry individuals, 42 South Asian ancestry individuals, 383 individuals
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