Active: Brain development Clear all

GWAS 2025-03-17

Cross-ancestry and sex-stratified genome-wide association analyses of amygdala and subnucleus volumes.

Ji Y, Liu N et al.

Nat Genet

The amygdala is a small but critical multi-nucleus structure for emotion, cognition and neuropsychia...

Mean volume of bilateral amygdala

2397

Participants

N/A

Studies

Details PubMed

GWAS 2024-07-15

Investigating grey matter volumetric trajectories through the lifespan at the individual level.

Shi R, Xiang S et al.

Nat Commun

Adolescents exhibit remarkable heterogeneity in the structural architecture of brain development. Ho...

Delayed neurodevelopment

7662

Participants

N/A

Studies

Details PubMed

GWAS 2024-03-26

Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study.

Tissink EP, Shadrin AA et al.

Nat Commun

Genetic pleiotropy is abundant across spatially distributed brain characteristics derived from one n...

MRI-derived phenotypes (MOSTest) (pleiotropy)

Replicated

47430

Participants

N/A

Studies

Details PubMed

GWAS 2024-03-04

Genetic architecture of the structural connectome.

Wainberg M, Forde NJ et al.

Nat Commun

Myelinated axons form long-range connections that enable rapid communication between distant brain r...

Left-hemisphere control network to right-hemisphere salience/ventral attention network white-matter structural connectivity

Replicated

26998

Participants

N/A

Studies

Details PubMed

GWAS 2023-11-12

Novel genome-wide associations for effort valuation and psychopathology in children and adults.

Nguyen NH, Mazza TM et al.

Am J Med Genet B Neuropsychiatr Genet

The Research Domain Criteria (RDoC) initiative was established by the US National Institute of Menta...

Effort expenditure for rewards task (EEfRT) hard-task choice

1270

Participants

N/A

Studies

Details PubMed

GWAS 2023-09-30

Genetic and neural bases of the neuroticism general factor.

Kim Y, Saunders GRB et al.

Biol Psychol

We applied structural equation modeling to conduct a genome-wide association study (GWAS) of the gen...

Neuroticism general factor

380000

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-26

Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.

Demontis D, Walters GB et al.

Nat Genet

Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with a ma...

Attention deficit hyperactivity disorder

225534

Participants

N/A

Studies

Details PubMed

GWAS 2022-11-16

Mapping gene by early life stress interactions on child subcortical brain structures: A genome-wide prospective study.

Bolhuis K, Mulder RH et al.

JCPP Adv

Although it is well-established that both genetics and the environment influence brain development, ...

Bilateral accumbens volume

Replicated

1049

Participants

N/A

Studies

Details PubMed

GWAS 2022-04-05

Genetic variants associated with longitudinal changes in brain structure across the lifespan.

Brouwer RM, Klein M et al.

Nat Neurosci

Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are ...

Amygdala volume change rate

15100

Participants

N/A

Studies

Details PubMed

GWAS 2021-04-05

Shared heritability of human face and brain shape.

Naqvi S, Sleyp Y et al.

Nat Genet

Evidence from model organisms and clinical genetics suggests coordination between the developing bra...

Brain shape (segment 91)

19670

Participants

N/A

Studies

Details PubMed

GWAS 2020-10-28

The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.

Li S, Weinstein G et al.

Brain Commun

Brain-derived neurotrophic factor (BDNF) plays an important role in brain development and function. ...

Brain-derived neurotrophic factor levels

11785

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-22

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.

Hofer E, Roshchupkin GV et al.

Nat Commun

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurologic...

Cortical surface area

Replicated

40980

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Cross-ancestry and sex-stratified genome-wide association analyses of amygdala and subnucleus volumes.

Ji Y, Liu N et al.

Nat Genet

Mean volume of bilateral amygdala

2025-03-17

Investigating grey matter volumetric trajectories through the lifespan at the individual level.

Shi R, Xiang S et al.

Nat Commun

Delayed neurodevelopment

2024-07-15

Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study.

Tissink EP, Shadrin AA et al.

Nat Commun

MRI-derived phenotypes (MOSTest) (pleiotropy)

2024-03-26

Genetic architecture of the structural connectome.

Wainberg M, Forde NJ et al.

Nat Commun

Left-hemisphere control network to right-hemisphere salience/ventral attention network white-matter structural connectivity

2024-03-04

Novel genome-wide associations for effort valuation and psychopathology in children and adults.

Nguyen NH, Mazza TM et al.

Am J Med Genet B Neuropsychiatr Genet

Effort expenditure for rewards task (EEfRT) hard-task choice

2023-11-12

Genetic and neural bases of the neuroticism general factor.

Kim Y, Saunders GRB et al.

Biol Psychol

Neuroticism general factor

2023-09-30

Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.

Demontis D, Walters GB et al.

Nat Genet

Attention deficit hyperactivity disorder

2023-01-26

Mapping gene by early life stress interactions on child subcortical brain structures: A genome-wide prospective study.

Bolhuis K, Mulder RH et al.

JCPP Adv

Bilateral accumbens volume

2022-11-16

Genetic variants associated with longitudinal changes in brain structure across the lifespan.

Brouwer RM, Klein M et al.

Nat Neurosci

Amygdala volume change rate

2022-04-05

Shared heritability of human face and brain shape.

Naqvi S, Sleyp Y et al.

Nat Genet

Brain shape (segment 91)

2021-04-05

The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.

Li S, Weinstein G et al.

Brain Commun

Brain-derived neurotrophic factor levels

2020-10-28

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.

Hofer E, Roshchupkin GV et al.

Nat Commun

Cortical surface area

2020-09-22