Active: Mortality Clear all

GWAS 2025-11-03

Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population.

Enzan N, Miyazawa K et al.

Nat Commun

To understand the genetic basis of heart failure (HF) in the Japanese population, we performed genom...

Heart failure

Replicated

1580320

Participants

N/A

Studies

Details PubMed

GWAS 2025-09-30

Genome-wide association study of susceptibility to acute respiratory distress syndrome.

Guillen-Guio B, Suarez-Pajes E et al.

EBioMedicine

Acute respiratory distress syndrome (ARDS) is a severe inflammatory process of the lung, often due t...

Acute respiratory distress syndrome

Replicated

6943

Participants

N/A

Studies

Details PubMed

GWAS 2025-09-17

Genome-wide association study meta-analysis uncovers novel genetic variants associated with olfactory dysfunction.

Imtiaz MA, Melas K et al.

BMC Genom Data

Olfactory dysfunction is among the earliest signs of many age-related neurodegenerative diseases and...

Olfactory dysfunction

22730

Participants

N/A

Studies

Details PubMed

GWAS 2025-08-01

Genome-wide association study of early-stage non-small cell lung cancer prognosis: a pooled analysis in the International Lung Cancer Consortium.

Dong M, Thakral A et al.

Carcinogenesis

Lung cancer is the leading cause of cancer mortality. To investigate genetic determinants for progno...

Late-stage non-small cell lung cancer

Replicated

3916

Participants

N/A

Studies

Details PubMed

GWAS 2025-06-11

A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging.

Libert S, Chekholko A et al.

Elife

Why people age at different rates is a fundamental, unsolved problem in biology. We created a model ...

Biological age difference (delta-Age)

133184

Participants

N/A

Studies

Details PubMed

GWAS 2025-05-13

Metabolome-wide association identifies ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.

Sadhu N, Dalan R et al.

Nat Cardiovasc Res

The burden of cardiovascular disease is rising in the Asia-Pacific region, in contrast to falling ca...

Tetradecadienoate (14:2) levels

1876

Participants

N/A

Studies

Details PubMed

GWAS 2025-05-08

Genome-wide association study for lung cancer in 6531 African Americans reveals new susceptibility loci.

Byun J, Han Y et al.

Hum Mol Genet

Despite lung cancer affecting all races and ethnicities, disparities are observed in incidence and m...

Lung adenocarcinoma

5274

Participants

N/A

Studies

Details PubMed

GWAS 2025-04-11

Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele.

Zhang X, Brody JA et al.

Nat Commun

Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide a...

Body mass index

Replicated

88873

Participants

N/A

Studies

Details PubMed

GWAS 2025-02-28

Rare genetic associations with human lifespan in UK Biobank are enriched for oncogenic genes.

Park J, Peña-Tauber A et al.

Nat Commun

Human lifespan is shaped by genetic and environmental factors. To enable precision health, understan...

Lifespan

393833

Participants

N/A

Studies

Details PubMed

GWAS 2025-02-18

Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy.

Tadros R, Zheng SL et al.

Nat Genet

Hypertrophic cardiomyopathy (HCM) is an important cause of morbidity and mortality with both monogen...

Hypertrophic cardiomyopathy

74259

Participants

N/A

Studies

Details PubMed

GWAS 2025-01-02

Circulating resistin levels and mutation burden of the RETN gene variants predict long-term mortality in a Taiwanese population.

Hsu LA, Teng MS et al.

Sci Rep

Human resistin is a proinflammatory cytokine involving the development and progression of cancer and...

Resistin levels

5678

Participants

N/A

Studies

Details PubMed

GWAS 2024-11-21

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.

Jurgens SJ, Rämö JT et al.

Nat Genet

Dilated cardiomyopathy (DCM) is a heart muscle disease that represents an important cause of morbidi...

Dilated cardiomyopathy

Replicated

2404278

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population.

Enzan N, Miyazawa K et al.

Nat Commun

Heart failure

2025-11-03

Genome-wide association study of susceptibility to acute respiratory distress syndrome.

Guillen-Guio B, Suarez-Pajes E et al.

EBioMedicine

Acute respiratory distress syndrome

2025-09-30

Genome-wide association study meta-analysis uncovers novel genetic variants associated with olfactory dysfunction.

Imtiaz MA, Melas K et al.

BMC Genom Data

Olfactory dysfunction

2025-09-17

Genome-wide association study of early-stage non-small cell lung cancer prognosis: a pooled analysis in the International Lung Cancer Consortium.

Dong M, Thakral A et al.

Carcinogenesis

Late-stage non-small cell lung cancer

2025-08-01

A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging.

Libert S, Chekholko A et al.

Elife

Biological age difference (delta-Age)

2025-06-11

Metabolome-wide association identifies ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.

Sadhu N, Dalan R et al.

Nat Cardiovasc Res

Tetradecadienoate (14:2) levels

2025-05-13

Genome-wide association study for lung cancer in 6531 African Americans reveals new susceptibility loci.

Byun J, Han Y et al.

Hum Mol Genet

Lung adenocarcinoma

2025-05-08

Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele.

Zhang X, Brody JA et al.

Nat Commun

Body mass index

2025-04-11

Rare genetic associations with human lifespan in UK Biobank are enriched for oncogenic genes.

Park J, Peña-Tauber A et al.

Nat Commun

Lifespan

2025-02-28

Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy.

Tadros R, Zheng SL et al.

Nat Genet

Hypertrophic cardiomyopathy

2025-02-18

Circulating resistin levels and mutation burden of the RETN gene variants predict long-term mortality in a Taiwanese population.

Hsu LA, Teng MS et al.

Sci Rep

Resistin levels

2025-01-02

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.

Jurgens SJ, Rämö JT et al.

Nat Genet

Dilated cardiomyopathy

2024-11-21