Active: Clin Cancer Res Clear all

GWAS 2022-06-02

Identification of Two Genetic Loci Associated with Leukopenia after Chemotherapy in Breast Cancer Patients.

Fasching PA, Liu D et al.

Clin Cancer Res

Purpose: To identify molecular predictors of grade 3/4 neutropenic or leukopenic events (NLE) after ...

Adverse response to chemotherapy in breast cancer (grade 3/4 neutropenic or leukopenic events)

3322

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-30

Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors.

Trendowski MR, Wheeler HE et al.

Clin Cancer Res

Purpose: Cisplatin is a first-line chemotherapeutic for many cancers, but causes neurotoxicity inclu...

Multiple severe cisplatin-induced neurotixicitiies in testicular cancer survivors

300

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-21

Genomic analysis of germline variation associated with survival of colorectal cancer patients treated with chemotherapy plus biologics in CALGB/SWOG 80405 (Alliance).

Innocenti F, Sibley AB et al.

Clin Cancer Res

Purpose: Irinotecan/5-fluorouracil (5-FU; FOLFIRI) or oxaliplatin/5-FU (FOLFOX), combined with bevac...

Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics

613

Participants

N/A

Studies

Details PubMed

GWAS 2019-07-11

Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy.

Trendowski MR, El-Charif O et al.

Clin Cancer Res

Purpose: Serum platinum is measurable for years after completion of cisplatin-based chemotherapy (CB...

Serum platinum levels after completion of cisplatin chemotherapy

1010

Participants

N/A

Studies

Details PubMed

GWAS 2019-04-05

Clinical and Genome-Wide Analysis of Cisplatin-Induced Tinnitus Implicates Novel Ototoxic Mechanisms.

El Charif O, Mapes B et al.

Clin Cancer Res

Purpose: Cisplatin, a commonly used chemotherapeutic, results in tinnitus, the phantom perception of...

Tinnitus in cisplatin-treated testicular cancer

762

Participants

N/A

Studies

Details PubMed

GWAS 2018-02-15

Genome-Wide Association Study Identifies a New Locus at 7q21.13 Associated with Hepatitis B Virus-Related Hepatocellular Carcinoma.

Li Y, Zhai Y et al.

Clin Cancer Res

Purpose: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. In China, chron...

Hepatitis B virus-related hepatocellular carcinoma

Replicated

7614

Participants

N/A

Studies

Details PubMed

GWAS 2016-12-30

Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity.

Wheeler HE, Gamazon ER et al.

Clin Cancer Res

Purpose: Cisplatin is one of the most commonly used chemotherapy drugs worldwide and one of the most...

Cisplatin-induced ototoxicity

Replicated

749

Participants

N/A

Studies

Details PubMed

GWAS 2016-12-19

Genome-Wide Association Study for Anthracycline-Induced Congestive Heart Failure.

Schneider BP, Shen F et al.

Clin Cancer Res

Purpose: Anthracycline-induced congestive heart failure (CHF) is a rare but serious toxicity associa...

Adverse response to chemotherapy (congestive heart failure) in breast cancer

Replicated

1620

Participants

N/A

Studies

Details PubMed

GWAS 2016-05-03

Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy.

Hertz DL, Owzar K et al.

Clin Cancer Res

Purpose: Discovery of SNPs that predict a patient's risk of docetaxel-induced neuropathy would enabl...

Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer

623

Participants

N/A

Studies

Details PubMed

GWAS 2016-04-08

A Genome-Wide Association Study Identifies a Novel Locus for Bortezomib-Induced Peripheral Neuropathy in European Patients with Multiple Myeloma.

Magrangeas F, Kuiper R et al.

Clin Cancer Res

Purpose: Painful peripheral neuropathy is a frequent toxicity associated with bortezomib therapy. Th...

Bortezomib-induced peripheral neuropathy in multiple myeloma

Replicated

583

Participants

N/A

Studies

Details PubMed

GWAS 2015-11-06

HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients with Cancer.

Xu CF, Johnson T et al.

Clin Cancer Res

Purpose: Pazopanib is an effective treatment for advanced renal cell carcinoma and soft-tissue sarco...

Response to Pazopanib in cancer (hepatotoxicity)

Replicated

2190

Participants

N/A

Studies

Details PubMed

GWAS 2015-07-02

Genome-Wide Association Studies for Taxane-Induced Peripheral Neuropathy in ECOG-5103 and ECOG-1199.

Schneider BP, Li L et al.

Clin Cancer Res

Purpose: Taxane-induced peripheral neuropathy (TIPN) is an important survivorship issue for many can...

Neuropathy in taxane-treated breast cancer

Replicated

2449

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Identification of Two Genetic Loci Associated with Leukopenia after Chemotherapy in Breast Cancer Patients.

Fasching PA, Liu D et al.

Clin Cancer Res

Adverse response to chemotherapy in breast cancer (grade 3/4 neutropenic or leukopenic events)

2022-06-02

Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors.

Trendowski MR, Wheeler HE et al.

Clin Cancer Res

Multiple severe cisplatin-induced neurotixicitiies in testicular cancer survivors

2020-09-30

Genomic analysis of germline variation associated with survival of colorectal cancer patients treated with chemotherapy plus biologics in CALGB/SWOG 80405 (Alliance).

Innocenti F, Sibley AB et al.

Clin Cancer Res

Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics

2020-09-21

Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy.

Trendowski MR, El-Charif O et al.

Clin Cancer Res

Serum platinum levels after completion of cisplatin chemotherapy

2019-07-11

Clinical and Genome-Wide Analysis of Cisplatin-Induced Tinnitus Implicates Novel Ototoxic Mechanisms.

El Charif O, Mapes B et al.

Clin Cancer Res

Tinnitus in cisplatin-treated testicular cancer

2019-04-05

Genome-Wide Association Study Identifies a New Locus at 7q21.13 Associated with Hepatitis B Virus-Related Hepatocellular Carcinoma.

Li Y, Zhai Y et al.

Clin Cancer Res

Hepatitis B virus-related hepatocellular carcinoma

2018-02-15

Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity.

Wheeler HE, Gamazon ER et al.

Clin Cancer Res

Cisplatin-induced ototoxicity

2016-12-30

Genome-Wide Association Study for Anthracycline-Induced Congestive Heart Failure.

Schneider BP, Shen F et al.

Clin Cancer Res

Adverse response to chemotherapy (congestive heart failure) in breast cancer

2016-12-19

Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy.

Hertz DL, Owzar K et al.

Clin Cancer Res

Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer

2016-05-03

A Genome-Wide Association Study Identifies a Novel Locus for Bortezomib-Induced Peripheral Neuropathy in European Patients with Multiple Myeloma.

Magrangeas F, Kuiper R et al.

Clin Cancer Res

Bortezomib-induced peripheral neuropathy in multiple myeloma

2016-04-08

HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients with Cancer.

Xu CF, Johnson T et al.

Clin Cancer Res

Response to Pazopanib in cancer (hepatotoxicity)

2015-11-06

Genome-Wide Association Studies for Taxane-Induced Peripheral Neuropathy in ECOG-5103 and ECOG-1199.

Schneider BP, Li L et al.

Clin Cancer Res

Neuropathy in taxane-treated breast cancer

2015-07-02