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GWAS 2024-06-13

Genome-wide association study and polygenic score assessment of insulin resistance.

Aliyu U, Umlai UI et al.

Front Endocrinol (Lausanne)

Insulin resistance (IR) and beta cell dysfunction are the major drivers of type 2 diabetes (T2D). Ge...

Homeostasis model assessment of insulin resistance

Replicated

6217

Participants

N/A

Studies

Details PubMed

GWAS 2024-02-02

Genome-wide association study of blood lipid levels in Southern Han Chinese adults with prediabetes.

Gao Z, Pu C et al.

Front Endocrinol (Lausanne)

Dyslipidemia is highly prevalent among individuals with prediabetes, further exacerbating their card...

Triglyceride levels

451

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-30

Investigating the shared genetic architecture between COVID-19 and obesity: a large-scale genome wide cross-trait analysis.

Chen Y, Fan C et al.

Front Endocrinol (Lausanne)

Observational studies have reported high comorbidity between obesity and severe COVID-19. The aim of...

COVID-19 infection or BMI (pleiotropy)

2985505

Participants

N/A

Studies

Details PubMed

GWAS 2023-10-05

Beyond apples and pears: sex-specific genetics of body fat percentage.

Roshandel D, Lu T et al.

Front Endocrinol (Lausanne)

Introduction: Biological sex influences both overall adiposity and fat distribution. Further, testos...

Body fat percentage (adjusted for testosterone and SHBG)

154337

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-15

Metabolic drivers of dysglycemia in pregnancy: ethnic-specific GWAS of 146 metabolites and 1-sample Mendelian randomization analyses in a UK multi-ethnic birth cohort.

Fuller H, Iles MM et al.

Front Endocrinol (Lausanne)

Introduction: Gestational diabetes mellitus (GDM) is the most common pregnancy complication worldwid...

Omega-3 fatty acids levels

3354

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-23

Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses.

Mansour A, Mousa M et al.

Front Endocrinol (Lausanne)

Type 2 diabetes mellitus (T2DM) is a chronic, metabolic disorder in which concomitant insulin resist...

Diabetic retinopathy in type 2 diabetes

310

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-22

Identification of shared genetic architecture between non-alcoholic fatty liver disease and type 2 diabetes: A genome-wide analysis.

Tan Y, He Q et al.

Front Endocrinol (Lausanne)

The incidence of complications of non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D...

Non-alcoholic fatty liver disease or type 2 diabetes

137039

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-27

Candidate loci shared among periodontal disease, diabetes and bone density.

Yu YH, Steffensen B et al.

Front Endocrinol (Lausanne)

Introduction: While periodontal disease (PD) has been associated with type 2 diabetes (T2D) and oste...

Periodontitis / loose teeth (MTAG)

506594

Participants

N/A

Studies

Details PubMed

GWAS 2022-06-13

A Genome-Wide Association Study of Prediabetes Status Change.

Liu T, Li H et al.

Front Endocrinol (Lausanne)

We conducted the first genome-wide association study of prediabetes status change (to diabetes or no...

Diabetes progression in prediabetes

Replicated

1414

Participants

N/A

Studies

Details PubMed

GWAS 2022-05-03

The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations.

Wang Z, Choi SW et al.

Front Endocrinol (Lausanne)

Polygenic risk scores (PRSs) aggregate the effects of genetic variants across the genome and are use...

Obesity

451145

Participants

N/A

Studies

Details PubMed

GWAS 2022-03-01

Genetic Variants Relate to Fasting Plasma Glucose, 2-Hour Postprandial Glucose, Glycosylated Hemoglobin, and BMI in Prediabetes.

Lin L, Fang T et al.

Front Endocrinol (Lausanne)

Diabetes mellitus (DM) is a chronic disease that seriously threatens human health. Prediabetes is a ...

Fasting plasma glucose in prediabetes

451

Participants

N/A

Studies

Details PubMed

GWAS 2021-06-22

Discovery Genome-Wide Association Study of Body Composition in 4,386 Adults From the UK Biobank's Pilot Imaging Enhancement Study.

Livingstone KM, Tan MH et al.

Front Endocrinol (Lausanne)

Body composition (fat, skeletal muscle and bone mass) is an important determinant of overall health ...

Body fat distribution (trunk fat ratio)

2294

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide association study and polygenic score assessment of insulin resistance.

Aliyu U, Umlai UI et al.

Front Endocrinol (Lausanne)

Homeostasis model assessment of insulin resistance

2024-06-13

Genome-wide association study of blood lipid levels in Southern Han Chinese adults with prediabetes.

Gao Z, Pu C et al.

Front Endocrinol (Lausanne)

Triglyceride levels

2024-02-02

Investigating the shared genetic architecture between COVID-19 and obesity: a large-scale genome wide cross-trait analysis.

Chen Y, Fan C et al.

Front Endocrinol (Lausanne)

COVID-19 infection or BMI (pleiotropy)

2024-01-30

Beyond apples and pears: sex-specific genetics of body fat percentage.

Roshandel D, Lu T et al.

Front Endocrinol (Lausanne)

Body fat percentage (adjusted for testosterone and SHBG)

2023-10-05

Metabolic drivers of dysglycemia in pregnancy: ethnic-specific GWAS of 146 metabolites and 1-sample Mendelian randomization analyses in a UK multi-ethnic birth cohort.

Fuller H, Iles MM et al.

Front Endocrinol (Lausanne)

Omega-3 fatty acids levels

2023-05-15

Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses.

Mansour A, Mousa M et al.

Front Endocrinol (Lausanne)

Diabetic retinopathy in type 2 diabetes

2023-03-23

Identification of shared genetic architecture between non-alcoholic fatty liver disease and type 2 diabetes: A genome-wide analysis.

Tan Y, He Q et al.

Front Endocrinol (Lausanne)

Non-alcoholic fatty liver disease or type 2 diabetes

2023-03-22

Candidate loci shared among periodontal disease, diabetes and bone density.

Yu YH, Steffensen B et al.

Front Endocrinol (Lausanne)

Periodontitis / loose teeth (MTAG)

2023-01-27

A Genome-Wide Association Study of Prediabetes Status Change.

Liu T, Li H et al.

Front Endocrinol (Lausanne)

Diabetes progression in prediabetes

2022-06-13

The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations.

Wang Z, Choi SW et al.

Front Endocrinol (Lausanne)

Obesity

2022-05-03

Genetic Variants Relate to Fasting Plasma Glucose, 2-Hour Postprandial Glucose, Glycosylated Hemoglobin, and BMI in Prediabetes.

Lin L, Fang T et al.

Front Endocrinol (Lausanne)

Fasting plasma glucose in prediabetes

2022-03-01

Discovery Genome-Wide Association Study of Body Composition in 4,386 Adults From the UK Biobank's Pilot Imaging Enhancement Study.

Livingstone KM, Tan MH et al.

Front Endocrinol (Lausanne)

Body fat distribution (trunk fat ratio)

2021-06-22