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GWAS 2022-03-14

Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations.

Temprano-Sagrera G, Sitlani CM et al.

J Thromb Haemost

Multi-phenotype analysis of genetically correlated phenotypes can increase the statistical power to ...

Von Willebrand factor levels or factor VIII levels or tissue plasminogen activator levels (pleiotropy)

105893

Participants

N/A

Studies

Details PubMed

GWAS 2021-09-17

Kallikrein augments the anticoagulant function of the protein C system in thrombin generation.

Wan J, Vadaq N et al.

J Thromb Haemost

Genetics play a significant role in coagulation phenotype and venous thromboembolism risk. Resistanc...

Thrombin generation parameter (lagtime)

327

Participants

N/A

Studies

Details PubMed

GWAS 2019-07-04

A Genome Wide Association Study on plasma FV levels identified PLXDC2 as a new modifier of the coagulation process.

Thibord F, Hardy L et al.

J Thromb Haemost

Factor V (FV) is a circulating protein primarily synthesized in the liver, and mainly present in pla...

Plasma factor V levels in venous thrombosis

Replicated

1666

Participants

N/A

Studies

Details PubMed

GWAS 2018-08-02

Genome-wide analysis of genetic determinants of circulating factor VII activating protease (FSAP) activity.

Olsson M, Stanne TM et al.

J Thromb Haemost

Essentials Knowledge of genetic regulators of plasma factor VII activating protease (FSAP) levels is...

Plasma factor VII activating protease levels

3126

Participants

N/A

Studies

Details PubMed

GWAS 2013-01-02

Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.

Athanasiadis G, Sabater-Lleal M et al.

J Thromb Haemost

β2 -Glycoprotein I (β2 -GPI), also designated apolipoprotein H, is a 50-kDa protein that circulates ...

β2-Glycoprotein I (β2-GPI) plasma levels

306

Participants

N/A

Studies

Details PubMed

GWAS 2012-06-05

A genome-wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24.2 and 9q.

Heit JA, Armasu SM et al.

J Thromb Haemost

Objectives: To identify venous thromboembolism (VTE) disease-susceptibility genes.

Venous thromboembolism

Replicated

5787

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations.

Temprano-Sagrera G, Sitlani CM et al.

J Thromb Haemost

Von Willebrand factor levels or factor VIII levels or tissue plasminogen activator levels (pleiotropy)

2022-03-14

Kallikrein augments the anticoagulant function of the protein C system in thrombin generation.

Wan J, Vadaq N et al.

J Thromb Haemost

Thrombin generation parameter (lagtime)

2021-09-17

A Genome Wide Association Study on plasma FV levels identified PLXDC2 as a new modifier of the coagulation process.

Thibord F, Hardy L et al.

J Thromb Haemost

Plasma factor V levels in venous thrombosis

2019-07-04

Genome-wide analysis of genetic determinants of circulating factor VII activating protease (FSAP) activity.

Olsson M, Stanne TM et al.

J Thromb Haemost

Plasma factor VII activating protease levels

2018-08-02

Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.

Athanasiadis G, Sabater-Lleal M et al.

J Thromb Haemost

β2-Glycoprotein I (β2-GPI) plasma levels

2013-01-02

A genome-wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24.2 and 9q.

Heit JA, Armasu SM et al.

J Thromb Haemost

Venous thromboembolism

2012-06-05