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GWAS Study

Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.

Tantisira KG, Lasky-Su J, Harada M et al.

21991891 PubMed ID
GWAS Study Type
2104 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

TK
Tantisira KG
LJ
Lasky-Su J
HM
Harada M
MA
Murphy A
LA
Litonjua AA
HB
Himes BE
LC
Lange C
LR
Lazarus R
SJ
Sylvia J
KB
Klanderman B
DQ
Duan QL
QW
Qiu W
HT
Hirota T
MF
Martinez FD
MD
Mauger D
SC
Sorkness C
SS
Szefler S
LS
Lazarus SC
LR
Lemanske RF
PS
Peters SP
LJ
Lima JJ
NY
Nakamura Y
TM
Tamari M
WS
Weiss ST
Chapter II

Abstract

Summary of the research findings

The response to treatment for asthma is characterized by wide interindividual variability, with a significant number of patients who have no response. We hypothesized that a genomewide association study would reveal novel pharmacogenetic determinants of the response to inhaled glucocorticoids.

1,169 European ancestry child and parent asthmatic cases

Chapter III

Study Statistics

Key metrics and study information

2104
Total Participants
GWAS
Study Type
Yes
Replicated
935 European ancestry adult asthmatic cases
Replication Participants
European
Ancestry
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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Analysis In Progress

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