Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust naive Bayes classification.
Sambo F, Malovini A, Sandholm N et al.
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Abstract
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Aims/hypothesis: Diabetic nephropathy is a major diabetic complication, and diabetes is the leading cause of end-stage renal disease (ESRD). Family studies suggest a hereditary component for diabetic nephropathy. However, only a few genes have been associated with diabetic nephropathy or ESRD in diabetic patients. Our aim was to detect novel genetic variants associated with diabetic nephropathy and ESRD.
661 European ancestry End-stage renal disease cases, 694 European ancestry Diabetic nephropathy cases, 472 European ancestry Microalbuminuria cases, 1,637 European ancestry controls
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