Genome-wide enriched pathway analysis of acute post-radiotherapy pain in breast cancer patients: a prospective cohort study.
Lee E, Takita C, Wright JL et al.
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Abstract
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Adjuvant radiotherapy (RT) can increase the risk of developing pain; however, the molecular mechanisms of RT-related pain remain unclear. The current study aimed to identify susceptibility loci and enriched pathways for clinically relevant acute post-RT pain, defined as having moderate to severe pain (pain score ≥ 4) at the completion of RT.
136 Hispanic cases, 75 European ancestry cases, 102 African ancestry cases, 45 cases, 265 Hispanic controls, 282 European ancestry controls, 194 African ancestry controls, 45 controls
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