Genome-wide association study of asthma exacerbations despite inhaled corticosteroids use.
Hernandez-Pacheco N, Vijverberg SJ, Herrera-Luis E et al.
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Abstract
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Rationale: Substantial variability in response to asthma treatment with inhaled corticosteroids (ICS) has been described among individuals and populations, suggesting the contribution of genetic factors. Nonetheless, only a few genes have been identified to date. We aimed to identify genetic variants associated with asthma exacerbations despite ICS use in European children and young adults and to validate the findings in non-Europeans. Moreover, we explored whether a gene-set enrichment analysis could suggest potential novel asthma therapies.
2,681 European ancestry individuals
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