Clinical laboratory test-wide association scan of polygenic scores identifies biomarkers of complex disease.
Dennis JK, Sealock JM, Straub P et al.
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Abstract
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Clinical laboratory (lab) tests are used in clinical practice to diagnose, treat, and monitor disease conditions. Test results are stored in electronic health records (EHRs), and a growing number of EHRs are linked to patient DNA, offering unprecedented opportunities to query relationships between genetic risk for complex disease and quantitative physiological measurements collected on large populations.
1,665 European ancestry individuals
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