Developing an optimal stratification model for colorectal cancer screening and reducing racial disparities in multi-center population-based studies.
Tian J, Zhang M, Zhang F et al.
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Abstract
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Early detection of colorectal neoplasms can reduce the colorectal cancer (CRC) burden by timely intervention for high-risk individuals. However, effective risk prediction models are lacking for personalized CRC early screening in East Asian (EAS) population. We aimed to develop, validate, and optimize a comprehensive risk prediction model across all stages of the dynamic adenoma-carcinoma sequence in EAS population.
15,714 European ancestry cases, 621,182 European ancestry controls, 7,062 East Asian ancestry cases, 195,745 East Asian ancestry controls
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