Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans.
Akinyemi RO, Tiwari HK, Srinivasasainagendra V et al.
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Abstract
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African ancestry populations have the highest burden of stroke worldwide, yet the genetic basis of stroke in these populations is obscure. The Stroke Investigative Research and Educational Network (SIREN) is a multicenter study involving 16 sites in West Africa. We conducted the first-ever genome-wide association study (GWAS) of stroke in indigenous Africans.
1,683 West African ancestry cases, 1,738 West African ancestry controls
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