Multi-trait association studies discover pleiotropic loci between Alzheimer's disease and cardiometabolic traits.
Bone WP, Siewert KM, Jha A et al.
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Abstract
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Identification of genetic risk factors that are shared between Alzheimer's disease (AD) and other traits, i.e., pleiotropy, can help improve our understanding of the etiology of AD and potentially detect new therapeutic targets. Previous epidemiological correlations observed between cardiometabolic traits and AD led us to assess the pleiotropy between these traits.
100,716 individuals with body fat percentage measurements, 71,880 Alzheimer's disease cases, 383,378 controls
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