Multi-omics analysis identifies CpGs near G6PC2 mediating the effects of genetic variants on fasting glucose.
Chung RH, Chiu YF, Wang WC et al.
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Abstract
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Aims/hypothesis: An elevated fasting glucose level in non-diabetic individuals is a key predictor of type 2 diabetes. Genome-wide association studies (GWAS) have identified hundreds of SNPs for fasting glucose but most of their functional roles in influencing the trait are unclear. This study aimed to identify the mediation effects of DNA methylation between SNPs identified as significant from GWAS and fasting glucose using Mendelian randomisation (MR) analyses.
18,122 Han Chinese ancestry individuals
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