Active: Frontotemporal dementia Clear all

GWAS 2023-09-28

Identifying risk loci for FTD and shared genetic component with ALS: A large-scale multitrait association analysis.

Chen K, Gao T et al.

Neurobiol Aging

Current genome-wide association studies of frontotemporal dementia (FTD) are underpowered due to lim...

Frontotemporal dementia (MTAG)

12928

Participants

N/A

Studies

Details PubMed

GWAS 2022-05-13

Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease.

Eissman JM, Dumitrescu L et al.

Brain

Approximately 30% of elderly adults are cognitively unimpaired at time of death despite the presence...

Cognitive resilience to Alzheimer's disease pathology x sex interaction in cognitively normal individuals (residual cognitive resilience model)

4407

Participants

N/A

Studies

Details PubMed

GWAS 2021-09-02

Genome-wide association study of frontotemporal dementia identifies a C9ORF72 haplotype with a median of 12-G4C2 repeats that predisposes to pathological repeat expansions.

Reus LM, Jansen IE et al.

Transl Psychiatry

Genetic factors play a major role in frontotemporal dementia (FTD). The majority of FTD cannot be ge...

Frontotemporal dementia

Replicated

5462

Participants

N/A

Studies

Details PubMed

GWAS 2020-10-21

The FAM171A2 gene is a key regulator of progranulin expression and modifies the risk of multiple neurodegenerative diseases.

Xu W, Han SD et al.

Sci Adv

Progranulin (PGRN) is a secreted pleiotropic glycoprotein associated with the development of common ...

Cerebrospinal fluid progranulin levels

Replicated

1362

Participants

N/A

Studies

Details PubMed

GWAS 2018-01-09

Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.

Broce I, Karch CM et al.

PLoS Med

Converging evidence suggests that immune-mediated dysfunction plays an important role in the pathoge...

Frontotemporal dementia and immune-mediated diseases (pleiotropy)

149010

Participants

N/A

Studies

Details PubMed

GWAS 2017-03-18

Differential Aging Analysis in Human Cerebral Cortex Identifies Variants in TMEM106B and GRN that Regulate Aging Phenotypes.

Rhinn H, Abeliovich A

Cell Syst

Human age-associated traits, such as cognitive decline, can be highly variable across the population...

Differential aging in older adults (frontal cortex)

Replicated

910

Participants

N/A

Studies

Details PubMed

GWAS 2017-01-23

Effects of Multiple Genetic Loci on Age at Onset in Frontotemporal Dementia.

Ferrari R, Grassi M et al.

J Alzheimers Dis

In frontotemporal dementia (FTD), age at disease onset (AAO) is unpredictable in both early and late...

Frontotemporal dementia (age at onset)

411

Participants

N/A

Studies

Details PubMed

GWAS 2015-06-12

A genome-wide screening and SNPs-to-genes approach to identify novel genetic risk factors associated with frontotemporal dementia.

Ferrari R, Grassi M et al.

Neurobiol Aging

Frontotemporal dementia (FTD) is the second most prevalent form of early onset dementia after Alzhei...

Frontotemporal dementia

1456

Participants

N/A

Studies

Details PubMed

GWAS 2015-03-17

A novel Alzheimer disease locus located near the gene encoding tau protein.

Jun G, Ibrahim-Verbaas CA et al.

Mol Psychiatry

APOE ɛ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of ot...

Alzheimer's disease (APOE e4 interaction)

Replicated

57914

Participants

N/A

Studies

Details PubMed

GWAS 2014-07-01

Frontotemporal dementia and its subtypes: a genome-wide association study.

Ferrari R, Hernandez DG et al.

Lancet Neurol

Frontotemporal dementia (FTD) is a complex disorder characterised by a broad range of clinical manif...

Frontotemporal dementia

Replicated

12928

Participants

N/A

Studies

Details PubMed

GWAS 2014-06-27

C9orf72 and UNC13A are shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: a genome-wide meta-analysis.

Diekstra FP, Van Deerlin VM et al.

Ann Neurol

Objective: Substantial clinical, pathological, and genetic overlap exists between amyotrophic latera...

Amyotrophic lateral sclerosis or frontotemporal dementia

Replicated

27257

Participants

N/A

Studies

Details PubMed

GWAS 2010-10-01

Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study.

Shatunov A, Mok K et al.

Lancet Neurol

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor neurons that results in ...

Amyotrophic lateral sclerosis

13844

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Identifying risk loci for FTD and shared genetic component with ALS: A large-scale multitrait association analysis.

Chen K, Gao T et al.

Neurobiol Aging

Frontotemporal dementia (MTAG)

2023-09-28

Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease.

Eissman JM, Dumitrescu L et al.

Brain

Cognitive resilience to Alzheimer's disease pathology x sex interaction in cognitively normal individuals (residual cognitive resilience model)

2022-05-13

Genome-wide association study of frontotemporal dementia identifies a C9ORF72 haplotype with a median of 12-G4C2 repeats that predisposes to pathological repeat expansions.

Reus LM, Jansen IE et al.

Transl Psychiatry

Frontotemporal dementia

2021-09-02

The FAM171A2 gene is a key regulator of progranulin expression and modifies the risk of multiple neurodegenerative diseases.

Xu W, Han SD et al.

Sci Adv

Cerebrospinal fluid progranulin levels

2020-10-21

Broce I, Karch CM et al.

PLoS Med

Frontotemporal dementia and immune-mediated diseases (pleiotropy)

2018-01-09

Differential Aging Analysis in Human Cerebral Cortex Identifies Variants in TMEM106B and GRN that Regulate Aging Phenotypes.

Rhinn H, Abeliovich A

Cell Syst

Differential aging in older adults (frontal cortex)

2017-03-18

Effects of Multiple Genetic Loci on Age at Onset in Frontotemporal Dementia.

Ferrari R, Grassi M et al.

J Alzheimers Dis

Frontotemporal dementia (age at onset)

2017-01-23

A genome-wide screening and SNPs-to-genes approach to identify novel genetic risk factors associated with frontotemporal dementia.

Ferrari R, Grassi M et al.

Neurobiol Aging

Frontotemporal dementia

2015-06-12

A novel Alzheimer disease locus located near the gene encoding tau protein.

Jun G, Ibrahim-Verbaas CA et al.

Mol Psychiatry

Alzheimer's disease (APOE e4 interaction)

2015-03-17

Frontotemporal dementia and its subtypes: a genome-wide association study.

Ferrari R, Hernandez DG et al.

Lancet Neurol

Frontotemporal dementia

2014-07-01

C9orf72 and UNC13A are shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: a genome-wide meta-analysis.

Diekstra FP, Van Deerlin VM et al.

Ann Neurol

Amyotrophic lateral sclerosis or frontotemporal dementia

2014-06-27

Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study.

Shatunov A, Mok K et al.

Lancet Neurol

Amyotrophic lateral sclerosis

2010-10-01