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GWAS 2022-10-13

Twelve loci associated with bone density in middle-aged and elderly Chinese: the Shanghai Changfeng Study.

Zeng H, Ge J et al.

J Clin Endocrinol Metab

Context: Previous genome-wide association studies (GWASs) of bone mineral density (BMD) were mainly ...

Bone mineral density at right intertrochanter (model 1)

3064

Participants

N/A

Studies

Details PubMed

GWAS 2022-03-19

A GWAS in idiopathic/unexplained infertile men detects a genomic region determining Follicle-stimulating hormone levels.

Schubert M, Pérez Lanuza L et al.

J Clin Endocrinol Metab

Context: Approximately 70% of infertile men are diagnosed with idiopathic (abnormal semen parameters...

Follicle stimulating hormone levels in idiopathic male infertility

Replicated

1865

Participants

N/A

Studies

Details PubMed

GWAS 2021-11-08

Genome-Wide Association Study And Polygenic Risk Scores Of Serum Dheas Levels In A Chilean Children Cohort.

Miranda JP, Lardone MC et al.

J Clin Endocrinol Metab

Context: Adrenarche reflects the developmental growth of the adrenal zona reticularis, which produce...

DHEAS levels

788

Participants

N/A

Studies

Details PubMed

GWAS 2021-07-13

Genome-Wide Association Study of Estradiol Levels, and the Causal Effect of Estradiol on Bone Mineral Density.

Schmitz D, Ek WE et al.

J Clin Endocrinol Metab

Context: Estradiol is the primary female sex hormone and plays an important role for skeletal health...

Estradiol levels

147690

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-29

Joint genome-wide association analyses identified 49 novel loci for age at natural menopause.

Zhang L, Wei XT et al.

J Clin Endocrinol Metab

Age at natural menopause (ANM) is an important index for women's health. Either early or late ANM is...

Age at menopause

181219

Participants

N/A

Studies

Details PubMed

GWAS 2021-04-23

Association of genetic variants for plasma LRG1 with rapid decline in kidney function in patients with type 2 diabetes.

Gurung RL, Dorajoo R et al.

J Clin Endocrinol Metab

Context: Elevated levels of plasma leucine-rich α-2-glycoprotein 1 (LRG1), a component of transformi...

Leucine-rich alpha-2-glycoprotein 1 levels in type 2 diabetes

Replicated

3694

Participants

N/A

Studies

Details PubMed

GWAS 2021-02-23

Genetic and Metabolic Determinants of Plasma Levels of ANGPTL8.

Oldoni F, Bass K et al.

J Clin Endocrinol Metab

Context: ANGPTL8 (A8) plays a key role in determining the tissue fate of circulating triglycerides (...

Plasma ANGPTL8 levels

3457

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-18

Genome-Wide Association Analysis of Pancreatic Beta Cell Glucose Sensitivity.

Deshmukh HA, Madsen AL et al.

J Clin Endocrinol Metab

Context: Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secreti...

Pancreatic beta-cell glucose sensitivity

Replicated

5706

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-16

Genome-wide association for HbA1c in Malay identified deletion on SLC4A1 that influences HbA1c independent of glycemia.

Chai JF, Kao SL et al.

J Clin Endocrinol Metab

Context: Glycated hemoglobin A1c (HbA1c) level is used to screen and diagnose diabetes. Genetic dete...

Glycated hemoglobin levels

1721

Participants

N/A

Studies

Details PubMed

GWAS 2020-07-11

A Genomewide Pharmacogenetic Study of Growth Hormone Responsiveness.

Dauber A, Meng Y et al.

J Clin Endocrinol Metab

Context: Individual patients vary in their response to growth hormone (GH). No large-scale genome-wi...

First year height change in growth hormone-treated short stature

Replicated

705

Participants

N/A

Studies

Details PubMed

GWAS 2019-12-03

Genome-wide analysis identifies two susceptibility loci for positive thyroid peroxidase and thyroglobulin antibodies.

Matana A, Boutin T et al.

J Clin Endocrinol Metab

Introduction: Thyroid peroxidase (TPO) and thyroglobulin (Tg) are main components of the thyroid gla...

Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels)

2613

Participants

N/A

Studies

Details PubMed

GWAS 2019-10-19

Genetic modifiers of cystic fibrosis-related diabetes have extensive overlap with type 2 diabetes and related traits.

Aksit MA, Pace RG et al.

J Clin Endocrinol Metab

Context: Individuals with cystic fibrosis (CF) develop a distinct form of diabetes characterized by ...

Cystic fibrosis-related diabetes in cystic fibrosis

Replicated

6331

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Twelve loci associated with bone density in middle-aged and elderly Chinese: the Shanghai Changfeng Study.

Zeng H, Ge J et al.

J Clin Endocrinol Metab

Bone mineral density at right intertrochanter (model 1)

2022-10-13

A GWAS in idiopathic/unexplained infertile men detects a genomic region determining Follicle-stimulating hormone levels.

Schubert M, Pérez Lanuza L et al.

J Clin Endocrinol Metab

Follicle stimulating hormone levels in idiopathic male infertility

2022-03-19

Genome-Wide Association Study And Polygenic Risk Scores Of Serum Dheas Levels In A Chilean Children Cohort.

Miranda JP, Lardone MC et al.

J Clin Endocrinol Metab

DHEAS levels

2021-11-08

Genome-Wide Association Study of Estradiol Levels, and the Causal Effect of Estradiol on Bone Mineral Density.

Schmitz D, Ek WE et al.

J Clin Endocrinol Metab

Estradiol levels

2021-07-13

Joint genome-wide association analyses identified 49 novel loci for age at natural menopause.

Zhang L, Wei XT et al.

J Clin Endocrinol Metab

Age at menopause

2021-05-29

Association of genetic variants for plasma LRG1 with rapid decline in kidney function in patients with type 2 diabetes.

Gurung RL, Dorajoo R et al.

J Clin Endocrinol Metab

Leucine-rich alpha-2-glycoprotein 1 levels in type 2 diabetes

2021-04-23

Genetic and Metabolic Determinants of Plasma Levels of ANGPTL8.

Oldoni F, Bass K et al.

J Clin Endocrinol Metab

Plasma ANGPTL8 levels

2021-02-23

Genome-Wide Association Analysis of Pancreatic Beta Cell Glucose Sensitivity.

Deshmukh HA, Madsen AL et al.

J Clin Endocrinol Metab

Pancreatic beta-cell glucose sensitivity

2020-09-18

Genome-wide association for HbA1c in Malay identified deletion on SLC4A1 that influences HbA1c independent of glycemia.

Chai JF, Kao SL et al.

J Clin Endocrinol Metab

Glycated hemoglobin levels

2020-09-16

A Genomewide Pharmacogenetic Study of Growth Hormone Responsiveness.

Dauber A, Meng Y et al.

J Clin Endocrinol Metab

First year height change in growth hormone-treated short stature

2020-07-11

Genome-wide analysis identifies two susceptibility loci for positive thyroid peroxidase and thyroglobulin antibodies.

Matana A, Boutin T et al.

J Clin Endocrinol Metab

Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels)

2019-12-03

Genetic modifiers of cystic fibrosis-related diabetes have extensive overlap with type 2 diabetes and related traits.

Aksit MA, Pace RG et al.

J Clin Endocrinol Metab

Cystic fibrosis-related diabetes in cystic fibrosis

2019-10-19