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GWAS 2025-01-30

Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis.

Zhang M, Su W et al.

J Transl Med

Psoriasis is a common chronic, recurrent, immune-mediated disease involved in the skin or joints or ...

Psoriasis

472819

Participants

N/A

Studies

Details PubMed

GWAS 2024-04-17

An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study.

Cheng Y, Wu L et al.

J Transl Med

Early-onset prostate cancer (EOPC, ≤ 55 years) has a unique clinical entity harboring high genetic r...

Prostate cancer

167517

Participants

N/A

Studies

Details PubMed

GWAS 2023-07-04

Association of non-high-density lipoprotein cholesterol trajectories with the development of non-alcoholic fatty liver disease: an epidemiological and genome-wide association study.

Lee JH, Kim J et al.

J Transl Med

Non-alcoholic fatty liver disease (NAFLD) shares common risk factors with cardiovascular diseases. E...

Nonalcoholic fatty liver disease

2203

Participants

N/A

Studies

Details PubMed

GWAS 2023-04-21

Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants.

Alemany S, Soler-Artigas M et al.

J Transl Med

Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interaction frequently accompanied...

Irritable bowel syndrome (MTAG)

887490

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-09

A two-stage genome-wide association study identifies novel germline genetic variations in CACNA2D3 associated with radiotherapy response in nasopharyngeal carcinoma.

Yu LL, Hu BW et al.

J Transl Med

Radiotherapy (RT) is the standard treatment for nasopharyngeal carcinoma (NPC). However, due to indi...

Response to radiotherapy in nasopharyngeal carcinoma (primary lesion efficacy)

Replicated

1166

Participants

N/A

Studies

Details PubMed

GWAS 2022-12-12

Genome-wide association study reveals ethnicity-specific SNPs associated with ankylosing spondylitis in the Taiwanese population.

Ko CL, Lin WZ et al.

J Transl Med

Ankylosing spondylitis (AS) is an autoimmune disease affecting mainly spine and sacroiliac joints an...

Ankylosing spondylitis

1442

Participants

N/A

Studies

Details PubMed

GWAS 2022-11-03

Evidence that the pituitary gland connects type 2 diabetes mellitus and schizophrenia based on large-scale trans-ethnic genetic analyses.

Cai L, Sun Y et al.

J Transl Med

Previous studies on European (EUR) samples have obtained inconsistent results regarding the genetic ...

Type 2 diabetes or schizophrenia (pleiotropy)

1466906

Participants

N/A

Studies

Details PubMed

GWAS 2022-09-05

Higher polygenic risk for melanoma is associated with improved survival in a high ultraviolet radiation setting.

Seviiri M, Scolyer RA et al.

J Transl Med

The role of germline genetic factors in determining survival from cutaneous melanoma (CM) is not wel...

Melanoma specific survival

Replicated

12929

Participants

N/A

Studies

Details PubMed

GWAS 2022-01-27

Polygenic risk and causal inference of psychiatric comorbidity in inflammatory bowel disease among patients with European ancestry.

Li Y, Bernstein CN et al.

J Transl Med

Approximately 40% of persons with inflammatory bowel disease (IBD) experience psychiatric comorbidit...

Psychiatric comorbidity in inflammatory bowel disease

240

Participants

N/A

Studies

Details PubMed

GWAS 2021-11-27

A two-stage genome-wide association study of radiation-induced acute toxicity in head and neck cancer.

Naderi E, Crijns APG et al.

J Transl Med

Most head and neck cancer (HNC) patients receive radiotherapy (RT) and develop toxicities. This geno...

radiation-induced toxicity (patient-rated acute xerostomia)

Replicated

1043

Participants

N/A

Studies

Details PubMed

GWAS 2021-02-25

Identification of susceptibility loci for cardiovascular disease in adults with hypertension, diabetes, and dyslipidemia.

Song Y, Choi JE et al.

J Transl Med

Hypertension (HTN), diabetes mellitus (DM), and dyslipidemia (DL) are well-known risk factors of car...

Cardio-cerebrovascular disease in hypertension

16302

Participants

N/A

Studies

Details PubMed

GWAS 2020-06-05

Genome-wide association study identifies genetic susceptibility loci and pathways of radiation-induced acute oral mucositis.

Yang DW, Wang TM et al.

J Transl Med

Radiation-induced oral mucositis (OM) is one of the most common acute complications for head and nec...

Response to radiotherapy in nasopharyngeal carcinoma (acute oral mucositis)

1467

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis.

Zhang M, Su W et al.

J Transl Med

Psoriasis

2025-01-30

An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study.

Cheng Y, Wu L et al.

J Transl Med

Prostate cancer

2024-04-17

Association of non-high-density lipoprotein cholesterol trajectories with the development of non-alcoholic fatty liver disease: an epidemiological and genome-wide association study.

Lee JH, Kim J et al.

J Transl Med

Nonalcoholic fatty liver disease

2023-07-04

Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants.

Alemany S, Soler-Artigas M et al.

J Transl Med

Irritable bowel syndrome (MTAG)

2023-04-21

A two-stage genome-wide association study identifies novel germline genetic variations in CACNA2D3 associated with radiotherapy response in nasopharyngeal carcinoma.

Yu LL, Hu BW et al.

J Transl Med

Response to radiotherapy in nasopharyngeal carcinoma (primary lesion efficacy)

2023-01-09

Genome-wide association study reveals ethnicity-specific SNPs associated with ankylosing spondylitis in the Taiwanese population.

Ko CL, Lin WZ et al.

J Transl Med

Ankylosing spondylitis

2022-12-12

Evidence that the pituitary gland connects type 2 diabetes mellitus and schizophrenia based on large-scale trans-ethnic genetic analyses.

Cai L, Sun Y et al.

J Transl Med

Type 2 diabetes or schizophrenia (pleiotropy)

2022-11-03

Higher polygenic risk for melanoma is associated with improved survival in a high ultraviolet radiation setting.

Seviiri M, Scolyer RA et al.

J Transl Med

Melanoma specific survival

2022-09-05

Polygenic risk and causal inference of psychiatric comorbidity in inflammatory bowel disease among patients with European ancestry.

Li Y, Bernstein CN et al.

J Transl Med

Psychiatric comorbidity in inflammatory bowel disease

2022-01-27

A two-stage genome-wide association study of radiation-induced acute toxicity in head and neck cancer.

Naderi E, Crijns APG et al.

J Transl Med

radiation-induced toxicity (patient-rated acute xerostomia)

2021-11-27

Identification of susceptibility loci for cardiovascular disease in adults with hypertension, diabetes, and dyslipidemia.

Song Y, Choi JE et al.

J Transl Med

Cardio-cerebrovascular disease in hypertension

2021-02-25

Genome-wide association study identifies genetic susceptibility loci and pathways of radiation-induced acute oral mucositis.

Yang DW, Wang TM et al.

J Transl Med

Response to radiotherapy in nasopharyngeal carcinoma (acute oral mucositis)

2020-06-05