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GWAS 2022-08-16

Longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study.

Allen RJ, Oldham JM et al.

Lancet Respir Med

Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease characterised by progressive scarri...

Forced vital capacity change in idiopathic pulmonary fibrosis

Replicated

1329

Participants

N/A

Studies

Details PubMed

GWAS 2020-11-13

Telomere length and risk of idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease: a mendelian randomisation study.

Duckworth A, Gibbons MA et al.

Lancet Respir Med

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease accounting for 1% of UK deaths. In the f...

Idiopathic pulmonary fibrosis

451025

Participants

N/A

Studies

Details PubMed

GWAS 2020-01-23

Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study.

Guillen-Guio B, Lorenzo-Salazar JM et al.

Lancet Respir Med

Acute respiratory distress syndrome (ARDS) is a lung inflammatory process caused mainly by sepsis. M...

Acute respiratory distress syndrome in sepsis

Replicated

1935

Participants

N/A

Studies

Details PubMed

GWAS 2019-07-17

Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations.

Dai J, Lv J et al.

Lancet Respir Med

Genetic variation has an important role in the development of non-small-cell lung cancer (NSCLC). Ho...

Squamous cell lung carcinoma

35705

Participants

N/A

Studies

Details PubMed

GWAS 2019-04-26

Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.

Pividori M, Schoettler N et al.

Lancet Respir Med

Childhood-onset and adult-onset asthma differ with respect to severity and comorbidities. Whether th...

Asthma (adult onset)

339801

Participants

N/A

Studies

Details PubMed

GWAS 2018-12-11

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.

Shrine N, Portelli MA et al.

Lancet Respir Med

Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel geneti...

Asthma (moderate or severe)

Replicated

57695

Participants

N/A

Studies

Details PubMed

GWAS 2018-12-05

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.

Rhodes CJ, Batai K et al.

Lancet Respir Med

Rare genetic variants cause pulmonary arterial hypertension, but the contribution of common genetic ...

Pulmonary arterial hypertension

11744

Participants

N/A

Studies

Details PubMed

GWAS 2018-03-15

Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study.

Hawcutt DB, Francis B et al.

Lancet Respir Med

A serious adverse effect of corticosteroid therapy is adrenal suppression. Our aim was to identify g...

Corticosteroid-induced adrenal suppression (peak cortisol < 350 nmol/L)

Replicated

488

Participants

N/A

Studies

Details PubMed

GWAS 2017-10-20

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.

Allen RJ, Porte J et al.

Lancet Respir Med

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with high mortality, uncer...

Idiopathic pulmonary fibrosis

Replicated

11321

Participants

N/A

Studies

Details PubMed

GWAS 2015-09-27

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank.

Wain LV, Shrine N et al.

Lancet Respir Med

Understanding the genetic basis of airflow obstruction and smoking behaviour is key to determining t...

Lung function in heavy smokers (low FEV1 vs high FEV1)

14654

Participants

N/A

Studies

Details PubMed

GWAS 2014-12-18

Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study.

Rautanen A, Mills TC et al.

Lancet Respir Med

Sepsis continues to be a major cause of death, disability, and health-care expenditure worldwide. De...

Sepsis from pneumonia (survival)

Replicated

2091

Participants

N/A

Studies

Details PubMed

GWAS 2014-02-07

Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.

Cho MH, McDonald ML et al.

Lancet Respir Med

The genetic risk factors for susceptibility to chronic obstructive pulmonary disease (COPD) are stil...

Chronic obstructive pulmonary disease (moderate to severe)

Replicated

14988

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study.

Allen RJ, Oldham JM et al.

Lancet Respir Med

Forced vital capacity change in idiopathic pulmonary fibrosis

2022-08-16

Telomere length and risk of idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease: a mendelian randomisation study.

Duckworth A, Gibbons MA et al.

Lancet Respir Med

Idiopathic pulmonary fibrosis

2020-11-13

Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study.

Guillen-Guio B, Lorenzo-Salazar JM et al.

Lancet Respir Med

Acute respiratory distress syndrome in sepsis

2020-01-23

Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations.

Dai J, Lv J et al.

Lancet Respir Med

Squamous cell lung carcinoma

2019-07-17

Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.

Pividori M, Schoettler N et al.

Lancet Respir Med

Asthma (adult onset)

2019-04-26

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.

Shrine N, Portelli MA et al.

Lancet Respir Med

Asthma (moderate or severe)

2018-12-11

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.

Rhodes CJ, Batai K et al.

Lancet Respir Med

Pulmonary arterial hypertension

2018-12-05

Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study.

Hawcutt DB, Francis B et al.

Lancet Respir Med

Corticosteroid-induced adrenal suppression (peak cortisol < 350 nmol/L)

2018-03-15

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.

Allen RJ, Porte J et al.

Lancet Respir Med

Idiopathic pulmonary fibrosis

2017-10-20

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank.

Wain LV, Shrine N et al.

Lancet Respir Med

Lung function in heavy smokers (low FEV1 vs high FEV1)

2015-09-27

Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study.

Rautanen A, Mills TC et al.

Lancet Respir Med

Sepsis from pneumonia (survival)

2014-12-18

Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.

Cho MH, McDonald ML et al.

Lancet Respir Med

Chronic obstructive pulmonary disease (moderate to severe)

2014-02-07