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GWAS 2020-06-17

Genomewide Association Study of Severe Covid-19 with Respiratory Failure.

Ellinghaus D, Degenhardt F et al.

N Engl J Med

There is considerable variation in disease behavior among patients infected with severe acute respir...

Severe COVID-19 infection with respiratory failure (analysis I)

3815

Participants

N/A

Studies

Details PubMed

GWAS 2017-09-07

Genetic Associations with Gestational Duration and Spontaneous Preterm Birth.

Zhang G, Feenstra B et al.

N Engl J Med

Despite evidence that genetic factors contribute to the duration of gestation and the risk of preter...

Preterm birth (maternal effect)

Replicated

52166

Participants

N/A

Studies

Details PubMed

GWAS 2017-04-27

Overexpression of the Cytokine BAFF and Autoimmunity Risk.

Steri M, Orrù V et al.

N Engl J Med

Genomewide association studies of autoimmune diseases have mapped hundreds of susceptibility regions...

Multiple sclerosis

Replicated

25344

Participants

N/A

Studies

Details PubMed

GWAS 2013-02-17

Genetic associations with valvular calcification and aortic stenosis.

Thanassoulis G, Campbell CY et al.

N Engl J Med

Limited information is available regarding genetic contributions to valvular calcification, which is...

Mitral annular calcification

Replicated

9838

Participants

N/A

Studies

Details PubMed

GWAS 2012-11-14

Variant of TREM2 associated with the risk of Alzheimer's disease.

Jonsson T, Stefansson H et al.

N Engl J Med

Sequence variants, including the ε4 allele of apolipoprotein E, have been associated with the risk o...

Alzheimer's disease

Replicated

24202

Participants

N/A

Studies

Details PubMed

GWAS 2012-07-19

Genetically distinct subsets within ANCA-associated vasculitis.

Lyons PA, Rayner TF et al.

N Engl J Med

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing ...

Antineutrophil cytoplasmic antibody-associated vasculitis

Replicated

9293

Participants

N/A

Studies

Details PubMed

GWAS 2012-03-29

HLA class II locus and susceptibility to podoconiosis.

Tekola Ayele F, Adeyemo A et al.

N Engl J Med

Podoconiosis is a tropical lymphedema resulting from long-term barefoot exposure to red-clay soil de...

Podoconiosis

Replicated

1003

Participants

N/A

Studies

Details PubMed

GWAS 2011-09-26

Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.

Tantisira KG, Lasky-Su J et al.

N Engl J Med

The response to treatment for asthma is characterized by wide interindividual variability, with a si...

Asthma treatment response

Replicated

2104

Participants

N/A

Studies

Details PubMed

GWAS 2011-07-06

Wnt signaling and Dupuytren's disease.

Dolmans GH, Werker PM et al.

N Engl J Med

Dupuytren's disease is a benign fibromatosis of the hands and fingers that leads to flexion contract...

Dupuytren's disease

Replicated

12126

Participants

N/A

Studies

Details PubMed

GWAS 2011-03-24

HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.

McCormack M, Alfirevic A et al.

N Engl J Med

Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthe...

Adverse response to carbamazepine

Replicated

4389

Participants

N/A

Studies

Details PubMed

GWAS 2011-02-22

Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.

Stanescu HC, Arcos-Burgos M et al.

N Engl J Med

Idiopathic membranous nephropathy is a major cause of the nephrotic syndrome in adults, but its etio...

Idiopathic membranous nephropathy

2894

Participants

N/A

Studies

Details PubMed

GWAS 2010-09-23

A large-scale, consortium-based genomewide association study of asthma.

Moffatt MF, Gut IG et al.

N Engl J Med

Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathw...

Asthma

26475

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genomewide Association Study of Severe Covid-19 with Respiratory Failure.

Ellinghaus D, Degenhardt F et al.

N Engl J Med

Severe COVID-19 infection with respiratory failure (analysis I)

2020-06-17

Genetic Associations with Gestational Duration and Spontaneous Preterm Birth.

Zhang G, Feenstra B et al.

N Engl J Med

Preterm birth (maternal effect)

2017-09-07

Overexpression of the Cytokine BAFF and Autoimmunity Risk.

Steri M, Orrù V et al.

N Engl J Med

Multiple sclerosis

2017-04-27

Genetic associations with valvular calcification and aortic stenosis.

Thanassoulis G, Campbell CY et al.

N Engl J Med

Mitral annular calcification

2013-02-17

Variant of TREM2 associated with the risk of Alzheimer's disease.

Jonsson T, Stefansson H et al.

N Engl J Med

Alzheimer's disease

2012-11-14

Genetically distinct subsets within ANCA-associated vasculitis.

Lyons PA, Rayner TF et al.

N Engl J Med

Antineutrophil cytoplasmic antibody-associated vasculitis

2012-07-19

HLA class II locus and susceptibility to podoconiosis.

Tekola Ayele F, Adeyemo A et al.

N Engl J Med

Podoconiosis

2012-03-29

Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.

Tantisira KG, Lasky-Su J et al.

N Engl J Med

Asthma treatment response

2011-09-26

Wnt signaling and Dupuytren's disease.

Dolmans GH, Werker PM et al.

N Engl J Med

Dupuytren's disease

2011-07-06

HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.

McCormack M, Alfirevic A et al.

N Engl J Med

Adverse response to carbamazepine

2011-03-24

Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.

Stanescu HC, Arcos-Burgos M et al.

N Engl J Med

Idiopathic membranous nephropathy

2011-02-22

A large-scale, consortium-based genomewide association study of asthma.

Moffatt MF, Gut IG et al.

N Engl J Med

Asthma

2010-09-23