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GWAS Study

Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection.

Packer RJ, Shrine N, Hall R et al.

37263751 PubMed ID
GWAS Study Type
77789 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

PR
Packer RJ
SN
Shrine N
HR
Hall R
MC
Melbourne CA
TR
Thompson R
WA
Williams AT
PM
Paynton ML
GA
Guyatt AL
AR
Allen RJ
LP
Lee PH
JC
John C
CA
Campbell A
HC
Hayward C
DV
de Vries M
VJ
Vonk JM
DJ
Davitte J
HE
Hessel E
MD
Michalovich D
BJ
Betts JC
SI
Sayers I
YA
Yeo A
HI
Hall IP
TM
Tobin MD
WL
Wain LV
Chapter II

Abstract

Summary of the research findings

Chronic sputum production impacts on quality of life and is a feature of many respiratory diseases. Identification of the genetic variants associated with chronic sputum production in a disease agnostic sample could improve understanding of its causes and identify new molecular targets for treatment.

9,714 European ancestry cases, 48,471 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

77789
Total Participants
GWAS
Study Type
Yes
Replicated
1,977 European ancestry cases, 17,627 European ancestry controls
Replication Participants
European
Ancestry
U.K.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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Analysis In Progress

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