Genome Wide Association Study of Preserved Ratio Impaired Spirometry (PRISm).
Higbee DH, Lirio A, Hamilton F et al.
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Abstract
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Preserved ratio impaired spirometry (PRISm) is defined as a forced expiratory volume in 1 s (FEV1) <80% predicted and FEV1/forced vital capacity ≥0.70. PRISm is associated with respiratory symptoms and comorbidities. Our objective was to discover novel genetic signals for PRISm and see if they provide insight into the pathogenesis of PRISm and associated comorbidities.
289,782 European ancestry individuals
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